Table 4.

Regional deposition fraction (DF) values (given in %) for simulations without condensational aerosol size change in the cannula, nostrils, and nasal cavity of each model. Also shown is the deposition efficiency (DE) of the total nasal region including the nostrils, nasal cavity, and nasopharynx. The particles considered include 0.9 μm and 1.5 μm solid formulations of 50:50 albuterol sulfate (AS):NaCl, and a 5 μm droplet of 0.1% AS:0.1% NaCl. The mean, 95% confidence interval (CI), and coefficient of variation (CV) for the total nasal DE of each initial particle size are also included.

	Cannula DF			Nostril DF			Nasal Cavity DF			Total Nasal DE
	0.9 μm	1.5 μm	5 μm	0.9 μm	1.5 μm	5 μm	0.9 μm	1.5 μm	5 μm	0.9 μm	1.5 μm	5 μm
Open	1.6	3.7	50.2	0.1	0.3	2.8	1.5	2.4	7.3	1.8	3.0	24.5
Average	1.7	3.5	49.6	0.3	0.4	5.1	2.2	3.5	11.5	2.6	4.2	38.6
Constricted1	1.6	2.8	49.4	0.2	0.3	2.9	2.0	3.0	16.4	2.4	3.7	45.1
Constricted2	1.7	2.9	48.5	0.2	0.3	7.9	2.4	3.5	16.5	2.7	4.1	54.9
							Mean			2.4	3.8	40.8
							95% CI			1.6-3.2	2.7-4.8	15.3-66.3
							CV			17%	15%	31%