Table 5.
Regional DF values (given in %) with condensational size change for the cannula, nostrils, and nasal cavity of each model. Also shown is the DE of the total nose-throat region including the nostrils, nasal cavity, and nasopharynx. The particles considered include 0.9 μm and 1.5 μm solid formulations of 50:50 AS:NaCl, and a 5 μm droplet of 0.1% AS:0.1% NaCl. The mean, 95% CI, and CV for the total nasal DE of each initial particle size are also included.
Cannula DF | Nostril DF | Nasal Cavity DF | Total Nasal DE | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||
0.9 μm | 1.5 μm | 5 μm | 0.9 μm | 1.5 μm | 5 μm | 0.9 μm | 1.5 μm | 5 μm | 0.9 μm | 1.5 μm | 5 μm | |
Open | 1.9 | 3.4 | 50.0 | 0.2 | 0.2 | 2.7 | 2.0 | 2.5 | 7.4 | 2.6 | 3.2 | 24.3 |
Average | 2.0 | 3.7 | 49.9 | 0.3 | 0.3 | 4.7 | 2.4 | 3.5 | 11.2 | 2.9 | 4.1 | 37.4 |
Constricted1 | 1.4 | 3.1 | 48.8 | 0.1 | 0.3 | 3.3 | 2.2 | 3.1 | 15.9 | 2.5 | 3.8 | 44.5 |
Constricted2 | 1.5 | 3.1 | 48.5 | 0.3 | 0.4 | 7.9 | 2.4 | 3.6 | 15.9 | 2.9 | 4.2 | 53.0 |
| ||||||||||||
Mean | 2.7 | 3.8 | 39.8 | |||||||||
95% CI | 2.3-3.1 | 2.9-4.7 | 15.5-64.1 | |||||||||
CV | 8% | 12% | 30% |