Table 7.

Penetration fraction (PF) values of each model, listed without simulated size change and with size change. The PF indicates the percentage of initial drug mass that exits the nasopharynx and enters the pharynx upstream of the larynx. Values include loss at the nostril inlets. The mean, 95% CI, and CV are listed for each initial particle size.

	Without Size Change			With Size Change
	900 nm	1.5 μm	5 μm	900 nm	1.5 μm	5 μm
Open	83.4	81.3	28.3	82.7	80.4	28.4
Average	80.0	77.3	24.6	79.6	76.4	25.0
Constricted1	85.7	83.3	22.1	85.5	83.4	22.7
Constricted2	80.6	78.4	18.6	81.1	77.5	19.7
Mean	82.4	80.1	23.4	82.2	79.4	24.0
95% CI	77.1 – 87.7	74.6 – 85.5	15.2 – 31.6	77.2 – 87.3	73.1 – 85.7	16.6 – 31.3
CV	3 %	3 %	17 %	3 %	4 %	15 %