Table 2.
Downregulated genes in hypoxic carotid arteries
| GeneSymbol | Gene Name | Fold Change | P Value | HRE + |
|---|---|---|---|---|
| ZNF146 | zinc finger protein 146 | 18.1 | 0.003 | + |
| POMP | proteasome maturation protein | 7.5 | 0.004 | + |
| BAG2 | BCL2-associated athanogene 2 | 6.3 | 0.019 | + |
| TM9SF1 | transmembrane 9 superfamily member 1 | 5.2 | 0.007 | + |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 4.9 | 0.044 | − |
| TSPAN14 | tetraspanin 14 | 4.2 | 0.043 | + |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 4.0 | 0.011 | + |
| INTS7 | integrator complex subunit 7 | 3.8 | 0.016 | + |
| C1QTNF1 | C1q and tumor necrosis factor related protein 1 | 3.8 | 0.025 | + |
| LOC100125916 | uncharacterized protein 100125016 | 3.6 | 0.011 | − |
| NPY1R | neuropeptide Y receptor Y1 | 3.6 | 0.026 | + |
| SLC35D2 | solute carrier family 35, member D2 | 3.4 | 0.046 | + |
| LOC607775 | uncharacterized LOC607775 | 3.3 | 0.023 | unknown |
| C3H1orf85 | chromosome 3 open reading frame, human C1orf85 | 3.3 | 0.002 | − |
| EGR1 | early growth response 1 | 3.2 | 0.011 | + |
| TNFAIP8L1 | tumor necrosis factor, alpha-induced protein 8-like 1 | 3.1 | 0.035 | − |
| SSFA2 | sperm specific antigen 2 | 3.0 | 0.002 | + |
| GJA5 | gap junction protein, alpha 5 | 3.0 | 0.040 | − |
| ART4 | ADP-ribosyltransferase 4 (Dombrock blood group) | 2.9 | 0.029 | − |
| TSPAN7 | tetraspanin 7 | 2.8 | 0.006 | + |
| BANP | BTG3 associated nuclear protein | 2.8 | 0.029 | + |
| PRMT7 | protein arginine methyltransferase 7 | 2.8 | 0.040 | + |
| MAPRE2 | microtubule-associated protein, RP/EB family, member 2 | 2.7 | 0.017 | + |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 2.6 | 0.049 | + |
| SIRT3 | sirtuin 3 | 2.6 | 0.037 | − |
| GFRA2 | glial cell line derived neurotrophic factor family receptor alpha 2 | 2.6 | 0.026 | + |
| FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) | 2.5 | 0.045 | − |
| CLMP | CXADR-like membrane protein | 2.5 | 0.007 | + |
| ELN | elastin | 2.4 | 0.045 | + |
| SLC26A11 | solute carrier family 26, member 11 | 2.4 | 0.033 | + |
| CD82 | CD82 molecule | 2.4 | 0.014 | + |
| DCAF11 | DDB1 and CUL4 associated factor 11 | 2.4 | 0.045 | + |
| OLFML1 | olfactomedin-like 1 | 2.4 | 0.032 | − |
| PIGS | phosphatidylinositol glycan anchor biosynthesis, class S | 2.4 | 0.034 | + |
| DPH2 | DPH2 homolog (S. cerevisiae) | 2.3 | 0.037 | + |
| MSX2 | msh homeobox 2 | 2.3 | 0.002 | + |
| IER3 | immediate early response 3 | 2.3 | 0.036 | + |
| BCL6 | B-cell CLL/lymphoma 6 | 2.3 | 0.037 | − |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 2.3 | 0.043 | + |
| ACVR1 | activin A receptor, type I | 2.3 | 0.026 | + |
| FAM113B | family with sequence similarity 113, member B | 2.3 | 0.029 | − |
| ABI1 | abl-interactor 1 | 2.3 | 0.045 | + |
| TMEM64 | transmembrane protein 64 | 2.3 | 0.013 | − |
| PRKCD | protein kinase C, delta | 2.3 | 0.003 | − |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 2.2 | 0.037 | + |
| CLC4 | chloride channel ClC4 | 2.2 | 0.006 | − |
| IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 2.1 | 0.024 | + |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 2.1 | 0.030 | + |
| SUB1 | SUB1 homolog (S. cerevisiae) | 2.1 | 0.031 | + |
| PTPLAD2 | protein tyrosine phosphatase-like A domain containing 2 | 2.1 | 0.014 | − |
| TOB1 | transducer of ERBB2, 1 | 2.1 | 0.041 | − |
| NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3 | 2.1 | 0.031 | + |
| DPF2 | D4, zinc and double PHD fingers family 2 | 2.1 | 0.032 | + |
| ENDOV | endonuclease V | 2.1 | 0.011 | + |
| LOC718351 | RING finger protein 185-like | 2.0 | 0.042 | − |
| RPRD1A | regulation of nuclear premRNA domain containing 1A | 2.0 | 0.037 | + |
| BHLHE40 | basic helix-loop-helix family, member e40 | 2.0 | 0.005 | + |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 2.0 | 0.022 | + |