Table 3.
Functional pathways represented by the genes altered in hypoxic carotid arteries
| Function | P Value | Molecules |
|---|---|---|
| Cell proliferation | 1.52E-06 | ABI1, ACVR1, AEBP1, ALDH1A1, APOA1, B3GNT2, BCL6, BHLHE40, BMP4, CD82, CRIP1, CRYAB, CXCL14, DCN, EGR1, ELN, ESR1, F3, FDFT1, FOLR2, FST, GFRA2, GJA5, IER3, IL18, IL6ST, LAPTM5, MAPRE2, MBP, MSX2, MYC, NPDC1, NPY1R, NQO2, OXT, POMC, PRKCD, PTN, SIRT3, SOCS2, TOB1, UCHL3 |
| Cell necrosis | 7.33E-04 | ALDH1A1, APOA1, BCL6, BHLHE40, BMP4, CD200, CES1, CRYAB, DCN, EGR1, ESR1, F3, FDFT1, FST, GFRA2, IER3, IL18, IL6ST, MBP, MSX2, MYC, NQO2, POMC, PRKCD, PTN, RAD23B, SIRT3, TNFAIP8L1 |
| Cell movement | 7.40E-05 | ACVR1, APOA1, BHLHE40, BMP4, CD200, CD82, CES1, CRYAB, CXCL14, DCN, EGR1, ELN, ESR1, F3, FST, IL18, IL6ST, MBP, MSX2, MYC, NQO2, POMC, PRKCD, PTN, RPRD1A, SOCS2 |
| Cell differentiation | 1.77E-04 | ABI1, ACVR1, BCL6, BHLHE40, BMP4, CD200, CD82, CDK5RAP3, DCN, EGR1, ESR1, FST, IL18, IL6ST, MBP, MSX2, MYC, NPY1R, OXT, PRKCD, PTN, SFXN1, SOCS2, TOB1, UCHL3 |
| Cell migration | 2.63E-04 | ACVR1, APOA1, BHLHE40, BMP4, CD200, CD82, CES1, CRYAB, CXCL14, DCN, EGR1, ELN, ESR1, F3, IL18, IL6ST, MSX2, MYC, NQO2, POMC, PRKCD, PTN, RPRD1A |
| Cellular development | 8.21E-08 | ABI1, ACVR1, APOA1, BCL6, BMP4, CRIP1, CRYAB, CXCL14, DCN, ELN, ESR1, F3, GJA5, IL18, IL6ST, MSX2, MYC, NPY1R, OXT, PRKCD, PTN, RAD23B |
| Transcription | 3.31E-03 | ACVR1, AEBP1, BCL6, BHLHE40, BMP4, CALCOCO1, CD82, CDK5RAP3, EGR1, ESR1, FST, IL18, IL6ST, MSX2, MYC, NPDC1, POMC, PRKCD, SOCS2, SUB1, ZNF146 |
| Cell size | 4.39E-06 | AEBP1, BCL6, BMP4, CXCL14, DCN, ESR1, F3, FST, GFRA2, IL6ST, MYC, NPY1R, POMC, PRKCD, RAD23B, SOCS2, SSFA2, UCHL3 |
| Vasculogenesis | 2.55E-06 | ABI1, ACVR1, APOA1, BMP4, CRYAB, CXCL14, DCN, ELN, ESR1, F3, IL18, MYC, OXT, PRKCD, PTN, RAD23B |
| Cell invasion | 6.88E-05 | BHLHE40, BMP4, CD82, CDK5RAP3, DCN, ESR1, F3, FST, IER3, IL18, MSX2, MYC, PRKCD, RPRD1A |
| Inflammatory response | 2.52E-04 | APOA1, BCL6, CD200, CXCL14, EGR1, ELN, IER3, IL18, IL6ST, NPY1R, POMC, PRKCD, PTN |
| Cellular morphology | 1.02E-03 | BMP4, CD200, EGR1, ESR1, FST, GFRA2, IL18, IL6ST, MBP, MSX2, MYC, NPY1R, UCHL3 |