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. 2014 Apr 10;4(2):131–141. doi: 10.3390/life4020131

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Scheme I — The canonical nucleotide 5ʹ-triphosphate polymerization reaction, employed by all extant polymerases, has a large equilibrium constant (K_eq ≈ 10⁶), greatly favoring product formation.