Table 1.
Characteristics of patients with inflammatory bowel disease, stratified by diagnosis of clostridium difficile infection
| Characteristic | With C difficile infection (n = 35) % |
Without C difficile infection (n = 3,153) % |
p-value |
|---|---|---|---|
| Mean age (SD) (in years) |
60.5 (16.9) | 48.7 (18.0) | 0.0001 |
| Female | 63 | 61 | 0.80 |
| Non-white | 11 | 13 | 0.82 |
| Charlson co-morbidity | < 0.001 | ||
| 0–2 | 8 | 47 | |
| ≥ 3 | 94 | 53 | |
| IBD type | 0.47 | ||
| Ulcerative colitis | 51 | 45 | |
| Crohn’s disease | 49 | 55 | |
| Recent hospitalization or surgery† |
95 | 55 | 0.009 |
| Antibiotic use† | 95 | 75 | 0.009 |
| Statin† | 31 | 17 | 0.02 |
| Steroids† | 29 | 53 | 0.003 |
| Proton pump inhibitor† |
63 | 48 | 0.08 |
| Immunosuppressive therapy |
20 | 7 | 0.003 |
| Mean plasma 25(OH)D (SD) (in ng/ml) |
20.4 (12.8) | 27.1 (12.7) | 0.002 |
†
- within 90 days of C difficile infection for cases