Table 1.
Sociodemographic and amygdala volumetric characteristics of 138 healthy Caucasian subjects carrying different 5-HTTLPR genotypes
| Demographic data | Males L/L genotype | Females L/L genotype | Males L/S genotype | Females L/S genotype | Males S/S genotype | Females S/S genotype | Genotype effect F (P) | Gender effect F (P) | Genotype by Gender interaction F (P) |
|---|---|---|---|---|---|---|---|---|---|
| N | 14 | 20 | 33 | 35 | 15 | 21 | |||
| Age (years) | 43.8 ± 15.6 | 35.6 ± 16.2 | 40.8 ± 15.7 | 44.3 ± 17.8 | 42.4 ± 15.6 | 40.0 ± 16.0 | F2,127 = 0.64 (0.52) | F2,127 = 0.07 (0.78) | F2,127 = 0.1.54 (0.21) |
| Educational level (years) | 13 (8–19) | 14 (5–20) | 14 (8–21) | 14 (8–24) | 15 (8–19) | 15 (8–21) | U = 0.61 (0.51) | U = 50 (0.61) | – |
| MMSE | 28.9 ± 1.5 | 29.5 ± 0.8 | 29.6 ± 0.6 | 29.1 ± 1.3 | 29.5 ± 0.8 | 29.6 ± 1 | F2,127 = 26 (0.77) | F2,127 = 0.17 (0.59) | F2,127 = 2.3 (0.1) |
| HAM-A | 6.7 ± 5.8 | 4.3 ± 4 | 4.03 ± 3.7 | 5.9 ± 4.1 | 3.0 ± 2.7 | 7.21 ± 5.1 | F2,127 = 0.15 (0.86) | F2,127 = 2.01 (0.16) | F2,127 = 4.2 (0.01) |
| Normalized left amygdala volume | 0.91 ± 0.09 | 0.9 ± 0.14 | 0.95 ± 0.16 | 0.89 ± 0.12 | 0.88 ± 0.13 | 1.02 ± 0.11 | F2,127 = 0.72 (0.49) | F2,127 = 1.02 (0.31) | F2,127 = 4.92 (0.008) |
| Normalized right amygdala volume | 1.05 ± 0.16 | 1.05 ± 0.17 | 1.06 ± 0.15 | 0.98 ± 0.16 | 0.95 ± 0.1 | 1.11 ± 0.13 | F2,127 = 0.36(0.69) | F2,127 = 1.19 (0.27) | F2,127 = 6.4 (0.002) |
Data are given as mean values ± SD or median values (range) when appropriate. HAM-A: Hamilton rating scale Anxiety. MMSE. Mini Mental State Examination.