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The Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) trial was a prospective, randomized, double-blind, placebo-controlled, multicenter trial that investigated the efficacy and safety of lower doses of conjugated equine estrogens (CEE) alone and with continuous medroxyprogesterone acetate (MPA) in early postmenopausal women (who were within 4 years of their last menstrual period).
