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. 2014 Jul 11;307(5):H689–H700. doi: 10.1152/ajpheart.00694.2013

Fig. 7.

Fig. 7.

Ucn2 increases intracellular cGMP and cAMP concentrations ([cGMP]i and [cAMP]i). A: intracellular cGMP concentration increases in the presence of Ucn2 (100 nM) as well as of spermine/NO (SNO; 100 μM) but does not change in myocytes treated with an inhibitor (ODQ; 10 μM) of soluble guanylyl cyclase (sGC). ODQ reduces the Ucn2-induced increase in [cGMP]i. B: Ucn2 (100 nM) also increases intracellular cAMP concentration. This effect is neither inhibited by ODQ nor mimicked by SNO; n = 8 for A and B. *P < 0.05 and **P < 0.01 vs. Ctrl; #P < 0.05 vs. Ucn2.