Table 1.
Baseline Characteristics of Patients With Symptomatic PAD
| Variable | Four Guideline Therapies (N=237) | Less Than Four Guideline Therapies (N=502) | P Value |
|---|---|---|---|
| Age, y | 68.9±10.7 | 66.5±13.2 | 0.02 |
| Male, % | 144 (61) | 279 (55) | 0.2 |
| Race/ethnicity, % | |||
| Caucasian | 178 (75) | 419 (83) | 0.03 |
| Hispanic | 24 (10) | 40 (8) | |
| African American | 24 (10) | 33 (7) | |
| Asian | 11 (5) | 10 (2) | |
| BMI, kg/m2 | 27.8±5.7 | 27.2±6.1 | 0.1 |
| Tobacco, former or current (%) | 166 (72) | 389 (79) | 0.04 |
| CHF, % | 70 (30) | 98 (20) | 0.002 |
| DM, % | 138 (58) | 226 (46) | 0.001 |
| GFR, mL/min | 66.6±33.2 | 71.0±41.8 | 0.4 |
| HTN, % | 224 (95) | 399 (80) | <0.001 |
| CAD, % | 156 (66) | 218 (44) | <0.001 |
| History of MI, % | 58 (24) | 81 (16) | 0.007 |
| Ejection fraction | 53.9±16.4 | 54.8±16.9 | 0.4 |
| History of stroke/TIA, % | 42 (18) | 85 (17) | 0.8 |
| History of malignancy, % | 20 (9) | 68 (14) | 0.05 |
| COPD, % | 30 (13) | 93 (19) | 0.05 |
| History of AAA, % | 13 (6) | 27 (5) | 0.96 |
| History of carotid stenosis, % | 44 (20) | 64 (14) | 0.04 |
| History of GI bleed, % | 10 (4) | 36 (7) | 0.1 |
| History of contralateral amputation, % | 18 (8) | 39 (8) | 0.3 |
| LDL, mg/dL | 78.4±28.7 | 92.0±40.0 | 0.004 |
| HBA1c, % | 7.4±2.2 | 7.9±2.1 | 0.04 |
| Beta blocker, % | 151 (64) | 241 (48) | <0.001 |
| Clopidogrel, % | 167 (70) | 291 (58) | 0.001 |
| Rutherford score | |||
| 1 | 11 (5) | 15 (3) | 0.3 |
| 2 | 49 (21) | 94 (19) | |
| 3 | 49 (21) | 83 (17) | |
| 4 | 17 (7) | 58 (12) | |
| 5 | 91 (39) | 197 (40) | |
| 6 | 16 (7) | 43 (9) | |
| ABI* | 0.54±0.23 | 0.53±0.22 | 0.8 |
AAA indicates abdominal aortic aneurysm; ABI, ankle brachial index; BMI, body mass index; CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; GFR, glomerular filtration rate; GI, gastrointestinal; HBA1c, hemoglobin A1c; HTN, hypertension; LDL, low‐density lipoprotein; MI, myocardial infarction; PAD, peripheral arterial disease; TIA, transient ischemic attack.
*
Excluding subjects with ABI >1.2, for whom toe brachial index was also measured.