Table 2.
Three‐Year Outcome Rates and Unadjusted and Adjusted Hazard Ratios
| Variables | Outcome Rates | Unadjusted | IPTW Adjusted | |||
|---|---|---|---|---|---|---|
| Four Guideline Therapies (N=237) | Less Than Four Guideline Therapies (N=502) | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| MACE | 56 (26%) | 137 (30%) | 0.83 (0.60 to 1.13) | 0.2 | 0.64 (0.45 to 0.89) | 0.009 |
| Death | 41 (19%) | 113 (25%) | 0.73 (0.51 to 1.05) | 0.09 | 0.56 (0.38 to 0.82) | 0.003 |
| MI | 13 (9%) | 28 (9%) | 0.95 (0.49 to 1.83) | 0.9 | 0.74 (0.36 to 1.48) | 0.4 |
| Stroke | 5 (4%) | 11 (4%) | 0.95 (0.33 to 2.73) | 0.9 | 0.89 (0.28 to 2.83) | 0.8 |
| MALE | 37 (19%) | 112 (28%) | 0.67 (0.46 to 0.98) | 0.04 | 0.55 (0.37 to 0.83) | 0.005 |
| Lower‐extremity bypass | 20 (10%) | 65 (16%) | 0.63 (0.38 to 1.04) | 0.07 | 0.55 (0.32 to 0.95) | 0.03 |
| Amputation | 19 (10%) | 49 (13%) | 0.82 (0.48 to 1.39) | 0.5 | 0.67 (0.38 to 1.18) | 0.2 |
| Death/amputation | 53 (24%) | 145 (31%) | 0.75 (0.55 to 1.02) | 0.07 | 0.60 (0.42 to 0.84) | 0.003 |
| MACE/MALE | 77 (34%) | 209 (44%) | 0.73 (0.56 to 0.95) | 0.02 | 0.60 (0.45 to 0.80) | 0.001 |
Unadjusted outcome rates are based on Kaplan‐Meier estimates. CI indicates confidence interval; HR, hazard ratio; IPTW, inverse probability of treatment weighting; MACE, major adverse cardiovascular and cerebrovascular events (MI, stroke, or death); MALE, major adverse limb events (lower‐extremity bypass or amputation); MI, myocardial infarction.