Table 3.

Associations Between Weight Change in Between Pregnancies and Risks of Diabetes, Hypertension and Dyslipidemia for 86 758 Women Free of Metabolic Disorders Who Gave Birth During Follow‐Up

Unadjusted	Diabetes		Hypertension		Dyslipidemia
	RR (95% CI)	IR/1000 PYs	RR (95% CI)	IR/1000 PYs	RR (95% CI)	IR/1000 PYs
Change in BMI
Weight loss, >1 kg/m2 (n=13 454; 15.5%)	1.40 (0.98 to 2.02)	1.0	1.28 (0.99 to 1.64)	0.8	1.40 (0.98 to 2.02)	1.0
Stable BMI, ±1 kg/m2 (n=44 277; 51.0%)	(ref)	0.7	(ref)	0.6	(ref)	0.7
Minor weight gain, >1 to 2 kg/m2 (n=13 414; 15.5%)	1.76 (1.26 to 2.48)	1.2	1.32 (1.02 to 1.70)	0.8	1.21 (0.82 to 1.78)	0.8
Major weight gain, >2 kg/m2 (n=15 643; 18.0%)	2.10 (1.54 to 2.85)	1.4	1.84 (1.48 to 2.29)	1.1	1.92 (1.40 to 2.63)	1.3

Multivariable analysis adjusted for BMI‐category, change in BMI, years between index‐pregnancy and first pregnancy during follow‐up, age and calendar year
	RR (95% CI)	RR (95% CI)	RR (95% CI)
BMI‐category
Underweight	1.01 (0.47 to 2.18)	1.03 (0.60 to 1.76)	1.32 (0.68 to 2.57)
Normal weight	(ref)	(ref)	(ref)
Overweight	2.20 (1.54 to 3.15)	1.72 (1.35 to 2.19)	1.55 (1.09 to 2.20)
Obese grade‐I	3.66 (2.38 to 5.63)	2.36 (1.71 to 3.24)	2.69 (1.75 to 4.12)
Obese grade‐II	7.14 (4.33 to 11.79)	2.95 (1.87 to 4.64)	2.62 (1.36 to 5.02)
Obese grade‐III	6.40 (3.10 to 13.22)	4.21 (2.36 to 7.51)	1.15 (0.28 to 4.72)
Change in BMI
Weight loss, >1 kg/m2	0.85 (0.57 to 1.27)	1.12 (0.80 to 1.44)	1.06 (0.71 to 1.60)
Stable BMI, ±1 kg/m2	(ref)	(ref)	(ref)
Minor weight gain, >1 to 2 kg/m2	1.43 (0.98 to 2.09)	1.24 (0.93 to 1.66)	1.03 (0.68 to 1.58)
Major weight gain, >2 kg/m2	1.38 (0.97 to 1.95)	1.66 (1.26 to 2.11)	1.50 (1.04 to 2.15)

95% CI indicates 95% confidence interval; BMI, body mass index; IR, incidence rate; PYs, person years; RR, rate ratio.