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. 2014 Apr 25;3(2):e000707. doi: 10.1161/JAHA.113.000707

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 4. — The graph shows the adjusted hazard ratio and 95% CI for the association between estimated glomerular filtration rates (GFR) and death or rehospitalization for cardiovascular events. Estimated GFR was modeled by restricted cubic splines with 4 knots (at 44, 67, 83, and 113) in a Cox regression model. The reference level was set at 90 mL/min per 1.73 m² for the estimation of hazard ratios. The Cox model was adjusted for age, sex, diabetes, chronic obstructive pulmonary disease, peripheral vascular disease, left ventricular ejection fraction, atrial fibrillation, prior myocardial infarction, prior heart failure, history of stroke, and acute kidney injury classified according to the Acute Kidney Injury Network (AKIN) criteria.