Table 1.
Baseline Characteristics Stratified by Choice of Early P2Y12 Antagonist
| Characteristics | Clopidogrel (N=147 176) | Prasugrel (N=32 941) | P Value |
|---|---|---|---|
| Age, y* | 64 (54, 75) | 57 (50, 64) | <0.0001 |
| Male | 66% | 77% | <0.0001 |
| Weight, kg* | 84 (72, 99) | 90 (78, 103) | <0.0001 |
| BMI, kg/m2 | 28.4 (25.1, 32.6) | 29.4 (26.1, 33.4) | <0.0001 |
| Insurance status | <0.0001 | ||
| HMO/private | 56% | 63% | |
| Medicare | 24% | 14% | |
| Medicaid | 4% | 4% | |
| Self/none | 12% | 17% | |
| Other | 1% | 1% | |
| Past medical history | |||
| Hypertension | 73% | 62% | <0.0001 |
| Hyperlipidemia | 62% | 55% | <0.0001 |
| Current smoker | 37% | 48% | <0.0001 |
| Diabetes mellitus | 31% | 25% | <0.0001 |
| Atrial fibrillation | 6% | 2% | <0.0001 |
| Prior MI | 26% | 19% | <0.0001 |
| Prior PCI | 27% | 23% | <0.0001 |
| Prior CABG | 15% | 7% | <0.0001 |
| Prior stroke | 8% | 2% | <0.0001 |
| Currently on dialysis | 2% | 1% | <0.0001 |
| Home medications | |||
| Aspirin | 43% | 33% | <0.0001 |
| Warfarin | 4% | 1% | <0.0001 |
| Clopidogrel | 20% | 7% | <0.0001 |
| Prasugrel | 0.2% | 4% | <0.0001 |
| Dual antiplatelet use | 16% | 9% | <0.0001 |
| Presentation Features | |||
| STEMI | 45% | 65% | <0.0001 |
| Systolic BP, mm Hg* | 145 (124, 166) | 145 (126, 165) | 0.80 |
| Baseline hemoglobin, g/dL* | 14 (2) | 15 (2) | <0.0001 |
| Heart failure or shock | 13% | 6% | <0.0001 |
| Baseline CrCl, mL/min*,* | 82 (56, 111) | 100 (78, 127) | <0.0001 |
BP indicates blood pressure; CABG, coronary artery bypass graft; CrCl, creatinine clearance (among non‐dialysis patients); HMO, Health Maintenance Organization; MI, myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST elevation myocardial infarction; VAMC, Veterans Affairs Medical Center.
*
Continuous variables expressed as medians (25th, 75th percentiles).
*
Estimated by the Cockcroft‐Gault formula.