Table 2.
Independent Factors Associated With Prasugrel (vs Clopidogrel) Selection
| Characteristics | OR | 95% CI | χ2 |
|---|---|---|---|
| Time since 2009 Q4 (per quarter) | 1.18 | 1.17 to 1.18 | 4727 |
| Age | 3157 | ||
| per 5 year ↑ age ≤75 | 1.02 | 1.00 to 1.04 | |
| per 5 year ↑ age >75 | 0.32 | 0.30 to 0.34 | |
| STEMI presentation | 1.81 | 1.75 to 1.87 | 1272 |
| Prior stroke | 0.38 | 0.35 to 0.42 | 433 |
| Healthcare insurance | 281 | ||
| Medicare vs HMO/private | 0.78 | 0.75 to 0.82 | |
| Self/none vs HMO/private | 0.79 | 0.76 to 0.82 | |
| Weight | 234 | ||
| per 5 kg ↓ ≤80 kg | 0.92 | 0.90 to 0.93 | |
| per 5 kg ↑ >80 kg | 1.00 | 1.00 to 1.01 | |
| Prior PCI | 1.26 | 1.21 to 1.32 | 99 |
| Initial creatinine, mg/dL | 0.88 | 0.85 to 0.90 | 89 |
| Prior CABG | 0.77 | 0.73 to 0.81 | 84 |
| Male | 1.15 | 1.12 to 1.18 | 75 |
| HF and/or shock on admission | 73 | ||
| HF only | 0.74 | 0.69 to 0.80 | |
| Shock | 0.87 | 0.80 to 0.94 | |
| Home warfarin | 0.64 | 0.58 to 0.72 | 63 |
| Heart rate (per 10 bpm ↑ > 60 bpm) | 0.97 | 0.96 to 0.98 | 62 |
| Race (white vs other) | 1.14 | 1.09 to 1.19 | 37 |
| Initial Hgb, g/dL | 1.02 | 1.02 to 1.03 | 27 |
| Home lipid‐lowering agent | 1.10 | 1.06 to 1.14 | 27 |
| Prior PAD | 0.86 | 0.80 to 0.92 | 20 |
| Hypertension | 0.93 | 0.90 to 0.96 | 17 |
| Home aspirin | 1.07 | 1.03 to 1.11 | 14 |
| Prior CHF | 0.87 | 0.81 to 0.94 | 14 |
Variables in the model include all those listed above and hyperlipidemia, diabetes, smoking status, prior MI, PCI, SBP, presentation Troponin and hospital features including teaching hospital, region, surgical capability. Hospital site was also in the model as a random effect. All variables in table are statistically significant (P<0.01 and χ2>10) and are listed in order of contribution to the model as measured by the chi‐square statistic. Non‐significant variables are listed above in this footnote. CHF indicates coronary heart failure; MI, myocardial infarction; PAD, peripheral arterial disease; PCI, percutaneous coronary intervention.