Table 1.

Echocardiographic Assessments of Change in Diastolic Function in Untreated SIV‐Infected Macaques Versus Maraviroc‐Treated SIV‐Infected Macaques

	Control Median (Interquartile Range)	SIV Median (Interquartile Range)	SIV+MVC Median (Interquartile Range)	P Value*
Number of macaques	8	22	6
Mitral valve
IVRT, ms	4.50 (−1.81 to 11.61)	8.95 (2.81 to 24.33)	−4.50 (−10.38 to −4.0)	0.0027
DT, ms	0.67 (−13.00 to 15.45)	56.0 (14.67 to 94.3)	−16.5 (−25.50 to 4.25)	0.0013
E, m/s	0.01 (−0.05 to 0.19)	−0.06 (−0.26 to 0.02)	0.03 (−0.04 to 0.22)	0.061
A, m/s	0.04 (−0.13 to 0.20)	0.08 (−0.10 to 0.18)	0.09 (0.00 to 0.23)	0.575
E/A	−0.05 (−0.24 to 0.23)	−0.3 (−0.62 to −0.08)	−0.09 (−0.42 to 0.14)	0.370
TDI septal
myoRT, ms	4.33 (−0.67 to 7.83)	11.5 (5.08 to 29.15)	−4.50 (−13.37 to 3.00)	0.0019
E', ms	−0.01 (−0.01 to 0.01)	−0.02 (−0.04 to 0.00)	0.01 (0.00 to 0.03)	0.0161
A', m/s	−0.02 (−0.04 to 0.23)	−0.50 (−0.76 to −0.2)	−0.06 (−0.35 to 0.00)	0.2824
E'/A'	−0.19 (−0.40 to 0.23)	−0.50 (−0.76 to −0.2)	−0.06 (−0.35 to 0.00)	0.0310
E/E'	0.81 (0.01 to 1.62)	0.34 (−0.60 to 2.14)	0.82 (−1.69 to 2.11)	0.8011
TDI lateral
myoRT, ms	3.45 (1.33 to 4.92)	20.67 (5.67 to 36.9)	−4.00 (−8.50 to −1.80)	0.0004
E', ms	0.00 (−0.04 to 0.03)	−0.01 (−0.05 to 0.02)	0.02 (−0.02 to 0.02)	0.2971
A', m/s	0.00 (−0.01 to 0.04)	0.01 (0.00 to 0.04)	0.00 (−0.10 to 0.03)	0.2976
E'/A'	−0.25 (−0.55 to 0.21)	−0.50 (−0.76 to 0.03)	0.28 (−0.42 to 0.65)	0.0468
E/E'	−5.02 (−6.72 to −3.86)	−2.51 (−5.6 to −0.67)	−0.65 (−2.42 to 0.66)	0.1236

Table values are change from baseline calculated by subtracting the baseline mean from the terminal or day 180 PI value. A indicates late diastolic wave; DT, E wave deceleration time; E, early diastolic wave; IVRT, isovolumetric relaxation time; MI, mitral inflow; MVC, maraviroc; myoRT, myocardial relaxation time; SIV, simian immunodeficiency virus; TDI, tissue Doppler imaging.

^*P value indicates Mann‐Whitney for SIV vs SIV+MVC using Prism 6.