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. 2014 Apr 25;3(2):e000588. doi: 10.1161/JAHA.113.000588

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 2. — Primary study end point. There was no significant increase in the conversion rate of the placebo arm (Fisher's exact test, placebo 5/294=1.7% vs verapamil 2/297=0.7%, P=0.28). Superiority margin for the primary end point was set as low as 5.0 percentage points. Since the 95% CI for the difference in effect of the 2 regimens overlaps zero not crossing the superiority margin, the strategy of preventive verapamil use may not be considered superior to the policy of ad hoc administration (difference in conversion rates 1.0%, 95% CI −1.1% to 3.3%).