Table 1.
Baseline Characteristics According to Quartiles of cTTR
| Baseline Characteristics | cTTR Q1 (0.0% to 50.6%) (N=3430) | cTTR Q2 (50.7% to 58.5%) (N=3563) | cTTR Q3 (58.6% to 65.7%) (N=3496) | cTTR Q4 (65.7% to 100%) (N=3508) | P Value |
|---|---|---|---|---|---|
| Age, y | 70 (62, 76) | 72 (64, 77) | 74 (66, 78) | 75 (68, 80) | <0.0001 |
| Female | 44% (1506) | 41% (1450) | 39% (1368) | 35% (1222) | <0.0001 |
| Race | <0.0001 | ||||
| White | 73% (2490) | 85% (3011) | 83% (2904) | 92% (3231) | |
| Black | 1% (33) | 2% (56) | 2% (55) | 1% (34) | |
| Asian | 22% (767) | 11% (393) | 13% (441) | 5% (169) | |
| Other | 4% (140) | 3% (103) | 3% (96) | 2% (74) | |
| Region | <0.0001 | ||||
| Asia/Pacific Islands | 22% (766) | 11% (405) | 13% (462) | 13% (455) | |
| Eastern Europe | 57% (1947) | 50% (1797) | 35% (1210) | 12% (426) | |
| Latin America | 11% (378) | 16% (556) | 16% (573) | 10% (359) | |
| North America | 5% (182) | 12% (417) | 17% (592) | 40% (1417) | |
| Western Europe | 5% (157) | 11% (388) | 19% (659) | 24% (851) | |
| BMI, kg/m2 | 27.7 (24.7, 31.6) | 28.2 (25.1, 31.8) | 28.3 (25.1, 32.0) | 28.7 (25.6, 32.6) | <0.0001 |
| Systolic BP, mean (SD) | 132.7 (15.6) | 132.2 (15.9) | 132.1 (16.4) | 131.6 (17.1) | 0.0031 |
| AF type | 0.0001 | ||||
| Persistent | 81% (2788) | 82% (2930) | 79% (2761) | 82% (2868) | |
| Paroxysmal | 18% (604) | 17% (600) | 20% (685) | 16% (575) | |
| New onset | 1% (38) | 1% (33) | 1% (50) | 2% (65) | |
| Hypertension | 90% (3100) | 92% (3276) | 91% (3180) | 89% (3115) | <0.0001 |
| Diabetes | 37% (1262) | 39% (1385) | 42% (1454) | 42% (1460) | <0.0001 |
| Prior stroke or TIA | 58% (1995) | 53% (1891) | 51% (1798) | 47% (1657) | <0.0001 |
| CHF | 71% (2448) | 70% (2478) | 61% (2129) | 49% (1711) | <0.0001 |
| eGFR (MDRD) | 69.4 (57.1, 81.0) | 68.6 (56.7, 81.6) | 66.6 (55.9, 78.5) | 68.4 (56.3, 78.7) | <0.0001 |
| Hemoglobin, g/dL | 14.3 (13.2, 15.4) | 14.2 (13.2, 15.2) | 14.2 (13.1, 15.2) | 14.1 (13.1, 15.1) | <0.0001 |
| CAD | 20% (686) | 21% (754) | 23% (816) | 29% (1018) | <0.0001 |
| COPD | 10% (347) | 10% (345) | 10% (348) | 12% (417) | 0.010 |
| PAD | 6% (193) | 5% (169) | 6% (227) | 6% (227) | 0.0039 |
| Prior GI bleed | 2% (80) | 2% (60) | 4% (151) | 6% (195) | <0.0001 |
| Liver disease | 7% (252) | 4% (158) | 5% (187) | 4% (137) | <0.0001 |
| Alcohol consumption (past 12 months) | <0.0001 | ||||
| Abstinent | 75% (2586) | 69% (2454) | 64% (2227) | 51% (1793) | |
| Light | 22% (747) | 27% (956) | 31% (1096) | 41% (1430) | |
| Moderate | 2% (71) | 3% (122) | 4% (147) | 7% (263) | |
| Heavy | 1% (26) | 1% (31) | 1% (25) | 1% (21) | |
| CHADS2, mean (SD) | 3.5 (0.9) | 3.5 (0.9) | 3.5 (1.0) | 3.3 (1.0) | <0.0001 |
| CHADS2 score | <0.0001 | ||||
| 2 | 11% (364) | 11% (383) | 13% (446) | 18% (641) | |
| 3 | 42% (1456) | 45% (1597) | 43% (1511) | 44% (1541) | |
| 4 | 32% (1102) | 29% (1035) | 29% (1006) | 25% (872) | |
| 5 | 13% (456) | 14% (484) | 13% (444) | 11% (384) | |
| 6 | 2% (52) | 2% (64) | 3% (89) | 2% (70) | |
| VKA use at screening | 41% (1403) | 56% (1998) | 69% (2400) | 83% (2925) | <0.0001 |
| Chronic aspirin at screening | 45% (1542) | 41% (1446) | 32% (1127) | 29% (1005) | <0.0001 |
Continuous variables are shown as median (25th, 75th percentiles), except where noted. Categorical variables are shown as percent (number). P value is from Pearson chi‐square test for categorical variables, from Kruskal‐Wallis test for continuous variables. AF indicates atrial fibrillation; BMI, body mass index; BP, blood pressure; CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; cTTR, center‐level time in therapeutic range; eGFR, glomerular filtration rate; GI, gastrointestinal; MDRD, Modification of Diet in Renal Disease; PAD, peripheral arterial disease; SD, standard deviation; TIA, transient ischemic attack; VKA, Vitamin K antagonist.