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. 2014 Apr 25;3(2):e000434. doi: 10.1161/JAHA.113.000434

Figure 6.

Figure 6.

MicroRNA‐23b (miR‐23b) is downregulated in cardiomyocytes of diabetic ischemic cardiomyopathy. A, miR‐23b expression in rat hearts as compared with other adult tissues, *P<0.0001 vs other tissues. B, miR‐23b levels in nCMs and arCMs compared with aortic endothelial cells (AoECs) and smooth muscle cells (AoSMCs). *P<0.0001 vs AoECs, AoSMCs, and nCMs. C, miR‐23b and miR‐1 levels in nCMs and arCMs; *P<0.0001 vs miR‐1, #P<0.01 vs nCMs. D, miR‐23b levels in the remote zone in the peri‐infarct zone of DM‐T2 compared with NDM; *P<0.0001 vs NDM, #P<0.0001 vs remote zone. E, The 48‐hour high glucose (HG) treatment of both NCMs and arCMs significantly reduced miR‐23b levels compared with low/normal glucose controls (CON); *P<0.001 vs CON. F, The 48‐hour HG treatment of both nCMs and arCMs significantly increased CA‐II mRNA levels in vitro compared with low/normal glucose controls (CON); *P<0.001 vs CON. All quantitative data are from 4 independent experiments. Quantitative data are expressed as mean±SE. arCM indicates adult ventricular cardiomyocyte; DM‐T2, diabetes mellitus type 2; nCM, neonatal cardiomyocyte; NDM, non–diabetes mellitus.