Figure 5.

Lack of IL‐6 negatively affects glucose tolerance in runners. (A) The mean fasting (baseline) blood glucose level (mmol·L⁻¹) for wild‐type (WT) and IL‐6 knockout (KO) groups with (RUN) and without (SED) voluntary access to running wheels after 3 weeks on a high‐fat diet. (B) The mean blood glucose levels above baseline (mmol·L⁻¹) following a bolus intraperitoneal injection of glucose in WT and KO groups (RUN & SED) after 3 weeks on a high‐fat diet. (C) The mean glucose area under the concentration–time curve above baseline (mmol·L⁻¹ glucose × 120 min) for WT and KO groups (RUN & SED) after 3 weeks on a high‐fat diet. ^aDenotes significant differences (P ≤ 0.05) between KO RUN and all other groups. Data are presented as mean ± SEM, (n = 6–8 per group).