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. 2014 Jul 4;2(7):e12064. doi: 10.14814/phy2.12064

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Liver protein expression of Akt, STAT3, SOCS3, leptin, and AMPKα from wild‐type (WT) and IL‐6 knockout (KO) groups with (RUN) and without (SED) voluntary access to running wheels fed a high‐fat diet for 4 weeks. Insulin‐stimulated (A) Akt^SER⁴⁷³ phosphorylation (B) STAT3^TYR⁷⁰⁶ phosphorylation (C) SOCS3 expression (D) Leptin expression (E) AMPKα^THR¹⁷² phosphorylation. ^aDenotes significant differences (P ≤ 0.05) between KO SED and all other groups. ^bDenotes significant differences (P ≤ 0.05) between WT and KO groups. Data are presented as mean ± SEM, (n = 6–8 per group). Ponceau S stains are shown as markers of equal protein loading.