Table 5.
Aldosterone‐regulated biological processes or molecular functions in the lung
| Number of genes | P | |
|---|---|---|
| Upregulated | ||
| ATP binding | 34 | 1.59×10−2 |
| DNA repair genes | 16 | 6.4×10−3 |
| Mitosis | 15 | 6.4×10−3 |
| Nuclear division | 15 | 6.4×10−3 |
| Cell cycle checkpoint | 12 | 6.4×10−3 |
| S phase of mitotic cell cycle | 11 | 4.0×10−4 |
| G1/S transition of mitotic cell cycle | 10 | 2.03×10−2 |
| G2/M transition of mitotic cell cycle | 8 | 2.57×10−2 |
| M/G1 transition of mitotic cell cycle | 8 | 1.1×10−3 |
| Helicase activity | 7 | 3.26×10−2 |
| DNA replication initiation | 6 | 3.0×10−4 |
| Histone‐lysine methyltransferase activity | 4 | 2.18×10−2 |
| Positive regulation of cell cycle cytokinesis | 3 | 2.03×10−2 |
| DNA replication‐dependent nucleosome assembly | 2 | 9.9×10−3 |
| Hexokinase activity | 2 | 2.20×10−2 |
| AMP response element binding | 2 | 2.69×10−2 |
| Downregulated | ||
| Phosphate containing compound metabolic process | 94 | 1.94×10−2 |
| Macromolecular complex assembly | 45 | 3.29×10−2 |
| Cytoskeleton organization | 39 | 2.48×10−2 |
| RNA binding | 39 | 2.31×10−2 |
| Negative regulator of apoptotic process | 33 | 1.24×10−2 |
| Protein kinase binding | 24 | 3.30×10−3 |
| Ubiquitin‐dependent protein catabolic process | 22 | 4.25×10−2 |
| Protein serine/threonine phosphate activity | 7 | 1.05×10−2 |
| Negative regulator of TOR signaling cascade | 5 | 1.24×10−2 |
| RNA helicase activity | 5 | 2.35×10−2 |
| Microtubule plus‐end binding | 4 | 6.20×10−3 |
| Fatty acid homeostasis | 4 | 1.24×10−2 |
| Positive regulator of cholesterol biosynthetic process | 3 | 1.94×10−2 |
| Positive regulator of chromatin silencing | 2 | 4.12×10−2 |
| AcetylCoA carboxylase kinase | 2 | 2.35×10−2 |
| Hydroxymethylglutaryl‐CoA reductase (NADPH) kinase activity | 2 | 2.35×10−2 |
Gene names that were statistically significant within each biological process can be found in Appendix.