Table 6.

Genes with differential expression after aldosterone infusion into one twin, validated by qRT‐PCR

GENE Protein	Function	Up/down regulated
AKR1C3: 3a HSD type IIb (HSD17B5)	Androgen synthesis and metabolism; prostaglandin F synthase (Lukacik et al. 2006) localized in conducting epithelia and associated with human fetal lung maturation (Provost and Tremblay 2007)	Up
CXCR4: chemokine CXC motif receptor 4	Stem cell/progenitor cell marker (Kucia et al. 2004) Expressed on circulating and amniotic fluid stem cells (Carraro et al. 2008) Mediates response to epithelial injury in lung (Gomperts et al. 2006)	Up
GZMB: granzyme B	Susanto et al. (2012) role in apoptosis and cytokine production in cytotoxic T cells and NK cells; role in Regulatory T‐cell response to inflammation and infection (Loebbermann et al. 2012; Hirota et al. 2013)	Up
NCAPH: non‐SMC condensin I complex, subunit H	Required for chromosome condensation and chromatid segregation during mitosis (Cabello et al. 2001)	Up
CAMP (ovine CATHL1B): Cathelicidin antimicrobial peptide or LL37	Antimicrobial peptide (Tomasinsig and Zanetti 2005); cell chemotaxis and immune mediation increase epithelial cell stiffness; decrease epithelial permeability in lung (Byfield et al. 2011a,b)	Down
(ovine SC5): cathelin‐related prepropeptide		Down

Gene and protein names in this table are those for the homologous human gene or protein; unless indicated these are the same in ovis aries or bos taurus. Functions are as determined in the cited literature.