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Model for shear stress activation of Als5p. (Top left) Model showing the domains of Als5p on the cell surface; the amyloid-forming sequences (red) are buried inside the folded T domains (yellow). (Top right) Under strong shear stress, the T domains unfold, the amyloid-forming sequences are exposed, and surface amyloid nanodomains form. (Bottom) If the amyloid-forming sequence is absent, as in Als5pV326N (left), or if the shear stress is weak, then the nanodomains cannot form.
