Rv0126 |
treS |
Trehalose synthase, cells lacking this gene are as virulent as wild-type in mice (346) |
Rv0350 |
hsp70 |
Heat shock protein 70, overexpression of heat shock proteins reduces survival of M. tuberculosis in the chronic phase of infection (347) |
Rv0353 |
hspR |
HspR repressor, reduced long-term survival in mice (347) |
Rv0467 |
icl |
Metabolism of fatty acids, reduced long-term survival in mice (213) |
Rv0470c |
pcaA |
Cyclopropane synthase, reduced long-term survival in mice (208) |
Rv0820, Rv0930 |
phoT, pstA
|
Stringent response, phosphate transport protein, growth in alveolar macrophage (62) |
Rv0981, Rv0982 |
mprA, mprB
|
Two-component regulator, reduced long-term survival in mice (348, 349) |
Rv1027/8c |
kdpDE |
Two-component regulator, increased lethality in mice (243) |
Rv1032c |
trcS |
Two-component regulator, increased lethality in mice (243) |
Rv1161 to -4 |
narGHJI |
Nitrate reductase, reduced long-term survival in mice (350, 351) |
Rv1221 |
sigE |
Regulates fatty acid degradation by Icl1, cell wall biosynthesis, prolonged time to death in mice (257, 272) |
Rv1736c |
narX |
Fused nitrate reductase, increased expression during hypoxia and in human granulomas (351) |
Rv1737c |
narK2 |
Nitrate/nitrite transport, increased expression during hypoxia and in human granulomas (352) |
Rv1832 |
gcvB |
Glycine decarboxylase, increased expression during hypoxia (353) |
Rv1908c |
katG |
Catalase-peroxidase, reduced long-term survival in mice (354) |
Rv2031c |
hspX |
α-Crystallin, increased expression during hypoxia and in mice (355) |
Rv2109c, Rv2110c |
prcBA |
Proteosome activity, required for long-term survival (212) |
Rv2583c |
relA |
Stringent response, (p)ppGpp synthase, reduced long-term survival in mice and guinea pigs (246, 255) |
Rv2710 |
sigB |
Adaptation to stationary-phase growth in nutrient-poor environment, nonessential gene (263) |
Rv2984, Rv0496 |
ppk1, ppx1
|
Poly(P) regulation, long-term survival in mice and guinea pigs (281, 283) |
Rv3132c |
dosR |
Two-component regulator, hypoxic response, increased lethality in mice (79, 230, 245, 356) |
Rv3139, Rv3140 |
fad E23, fadE24
|
Induced by INH, component of shunt pathway, detoxify accumulated fatty acids (357, 358) |
Rv3223c |
sigH |
Regulates structural genes, DNA repair protein, enzymes in thiol metabolism, reduced pathology, prolonged time to death (265, 267, 270) |
Rv3286c |
sigF |
Regulation of genes in early and late stationary phase, prolonged time to death in mice (359) |
Rv3416 |
whiB3 |
Transcriptional regulator, reduced pathology, prolonged time to death (227) |
Rv3583c |
carD |
rRNA transcription, essential for survival in mice (288, 360) |
Rv3764/5c |
tcrY |
Two-component regulator, increased lethality in mice (243) |