TABLE 2.
M. tuberculosis genes implicated in LTBI
| Rv no. | Gene(s) | Importance and/or phenotypes (reference[s]) |
|---|---|---|
| Rv0126 | treS | Trehalose synthase, cells lacking this gene are as virulent as wild-type in mice (346) |
| Rv0350 | hsp70 | Heat shock protein 70, overexpression of heat shock proteins reduces survival of M. tuberculosis in the chronic phase of infection (347) |
| Rv0353 | hspR | HspR repressor, reduced long-term survival in mice (347) |
| Rv0467 | icl | Metabolism of fatty acids, reduced long-term survival in mice (213) |
| Rv0470c | pcaA | Cyclopropane synthase, reduced long-term survival in mice (208) |
| Rv0820, Rv0930 | phoT, pstA | Stringent response, phosphate transport protein, growth in alveolar macrophage (62) |
| Rv0981, Rv0982 | mprA, mprB | Two-component regulator, reduced long-term survival in mice (348, 349) |
| Rv1027/8c | kdpDE | Two-component regulator, increased lethality in mice (243) |
| Rv1032c | trcS | Two-component regulator, increased lethality in mice (243) |
| Rv1161 to -4 | narGHJI | Nitrate reductase, reduced long-term survival in mice (350, 351) |
| Rv1221 | sigE | Regulates fatty acid degradation by Icl1, cell wall biosynthesis, prolonged time to death in mice (257, 272) |
| Rv1736c | narX | Fused nitrate reductase, increased expression during hypoxia and in human granulomas (351) |
| Rv1737c | narK2 | Nitrate/nitrite transport, increased expression during hypoxia and in human granulomas (352) |
| Rv1832 | gcvB | Glycine decarboxylase, increased expression during hypoxia (353) |
| Rv1908c | katG | Catalase-peroxidase, reduced long-term survival in mice (354) |
| Rv2031c | hspX | α-Crystallin, increased expression during hypoxia and in mice (355) |
| Rv2109c, Rv2110c | prcBA | Proteosome activity, required for long-term survival (212) |
| Rv2583c | relA | Stringent response, (p)ppGpp synthase, reduced long-term survival in mice and guinea pigs (246, 255) |
| Rv2710 | sigB | Adaptation to stationary-phase growth in nutrient-poor environment, nonessential gene (263) |
| Rv2984, Rv0496 | ppk1, ppx1 | Poly(P) regulation, long-term survival in mice and guinea pigs (281, 283) |
| Rv3132c | dosR | Two-component regulator, hypoxic response, increased lethality in mice (79, 230, 245, 356) |
| Rv3139, Rv3140 | fad E23, fadE24 | Induced by INH, component of shunt pathway, detoxify accumulated fatty acids (357, 358) |
| Rv3223c | sigH | Regulates structural genes, DNA repair protein, enzymes in thiol metabolism, reduced pathology, prolonged time to death (265, 267, 270) |
| Rv3286c | sigF | Regulation of genes in early and late stationary phase, prolonged time to death in mice (359) |
| Rv3416 | whiB3 | Transcriptional regulator, reduced pathology, prolonged time to death (227) |
| Rv3583c | carD | rRNA transcription, essential for survival in mice (288, 360) |
| Rv3764/5c | tcrY | Two-component regulator, increased lethality in mice (243) |