Amino acid alignment of Msed_1517 variants from thermoacidophiles. The line length corresponds to the open reading frame. The solid portions indicate regions of conservation, and the dashed portions indicate regions of divergence. Mse, Metallosphaera sedula DSM5348T; CuR1, spontaneous copper resistant derivative of
M. sedula; Mye, Metallosphaera yellowstonensis MK1; Mcu, Metallosphaera cuprina Ar-4; Sso, Sulfolobus solfataricus 98/2.