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STAT3 activation, ER stress, and inflammation are present in the CNS during EAE. (A) Mice were immunized with MOG peptide to induce EAE, and disease was scored over time. Brain tissue was collected from EAE mice at the indicated time points and analyzed by immunoblotting (B) or by reverse transcription-quantitative PCR (qRT-PCR) (C). (D) Spinal cord tissue was collected from EAE mice at the indicated time points and analyzed by qRT-PCR.
