FIG 1.

JMJD1A is downregulated in human germ cell tumors. (A) Box-and-whisker plot of JMJD1A gene expression in human germ cell tumors (teratomas) compared to normal testes (31) analyzed using the Oncomine compendium of cancer transcriptome microarray profiles (http://www.oncomine.org/). (B) Box-and-whisker plot of JMJD1A expression scores in different subtypes of germ cell tumors graded as described in Materials and Methods (P < 0.01). (C) Human germ cell tumors contain fewer JMJD1A-positive cells. Representative tissue sections from normal testes adjacent to cancer, seminomas, yolk sac tumors, and embryonal carcinomas were immunohistologically stained with anti-JMJD1A antibodies (brown) and counterstained with hematoxylin (blue). Scale bars, 200 μm.