FIG 3.

Transplant recipients of Sec23b^gt/gt FLC do not exhibit CDAII. (A and B) Mice transplanted with Sec23b^gt/gt FLC demonstrated equivalent hemoglobin (A) and hematocrit (B) levels compared to mice transplanted with control WT FLC over the course of 25 weeks of posttransplantation follow-up (P > 0.05 for all time points). n = 5 to 7 mice per group. Error bars represent standard deviations. (C) Spleens harvested from transplant recipients of Sec23b^gt/gt and WT FLC were equivalent in weights. Recipients of Sec23b^gt/gt FLC exhibited equivalent myeloid:erythroid ratios (D) and number of bi/multinucleated RBC precursors (E; evaluated independently by two investigators) compared to control mice transplanted with WT FLC. Each dot represents results from one mouse. Horizontal lines indicate means, and error bars indicate standard deviations.