FIG 4.

(A) Prevalence of the A2058G and A2059G mutations in treponemal 23S rRNA genes isolated from clinical samples from syphilis patients in the Czech Republic from 2007 to 2013. Data from 2007 to 2010 are from a previous study in the Czech Republic (5). While the prevalence of A2058G appears to be increasing, the prevalence of A2059G is relatively low and appears to be decreasing. The relative prevalence of mutations in the 23S rRNA gene locus since 2007 is shown because no isolates harboring these mutations were found in 2004 or 2005. In 2006, only one isolate harboring A2058G was identified. (B) Macrolide antibiotic use in the Czech Republic from 2007 to 2013. Data were provided by the State Institute for Drug Control in the Czech Republic. Antibiotic use is shown as the number of medical product packages representing the dose most frequently used for the treatment of a single patient.