TABLE 6.

Strain 1861 specifically differentially regulates a subset of genes involved in the IFN-I response^a

Gene symbol	Strain 1861 vs strain 1
	Fold change	Significance
Bst2	7.89	*
Crp	4.73	*
H2-k1	2.55	**
Nos2	2.76	*
Traf3	−2.13	*

^aAnimals (n = 4 per group) were challenged with 10⁷ CFU of strain 1 or strain 1861 or left unchallenged (“resting”). Lungs were harvested for RNA isolation at 6 h postchallenge, and immune response gene expression was analyzed using mouse type I interferon response RT² Profiler PCR arrays (cutoff used, fold change ≥ 2). Data represent changes in gene expression in lungs from animals challenged with strain 1861 relative to lungs from animals challenged with strain 1. *, P < 0.05; **, P < 0.01.