FIG 3.

Chemokine and PTX3 levels in A. baumannii-challenged mice. In vivo production of PTX3 and chemokines was determined as described in Materials and Methods. (A) Serum PTX3 levels were monitored over a 24-h period (n = 6) in mice challenged with A. baumannii strain CI 77 or 79. The gray bar indicates basal PTX3 production observed in the mock control group over 24 h (mean ± 1 SD). (B) Chemokines KC, MCP-1, and RANTES (mock, n = 22; CI 77, n = 24; CI 79, n = 12) were assessed 24 h postchallenge, as were serum MPO levels (n = 6). Error bars represent ±SD in all graphs; statistical differences were determined by the Welch t test; *, P < 0.05; **, P < 0.005; ***, P < 0.0005.