FIG 8.

B. pertussis-induced pathology is reduced by acetazolamide (ACTZ) treatment. C57BL/6 mice (n = 8) were inoculated with B. pertussis and treated daily with vehicle or ACTZ via subcutaneous injection. (A to C) ACTZ treatment caused a slight increase in bacterial lung burden (A) and no change in pendrin protein production (B). However, lung pathology was significantly lower in ACTZ-treated mice as determined by pathology score (C). Bars represent mean ± SEM. (D to G) Representative H&E-stained histology images.