FIG 1.

Alveolar bone resorption and gingival RANKL concentrations following 2 weeks of treatment in WT, Tlr2^−/−, and Tlr4^−/− mice. (A) Alveolar bone resorption around maxillary second molars (left and right), induced by ligation or ligation plus P. gingivalis infection, was analyzed after 2 weeks of treatment of WT, Tlr2^−/−, and Tlr4^−/− mice and is presented as the area of bone loss (mm²). (B) Total protein was isolated from gingival tissues, and the RANKL concentration was analyzed by ELISA using a specific antibody. The nontreatment groups were used as controls. Data are means and SE (n = 10).