TABLE 1.

Dosing and infusion rates in the single-dose escalation study for assessing the tolerability of i.v. nemonoxacin

Group	Dose (mg)	Vol of liquid (ml)	No. of subjects (investigational drug + placebo)a	Infusion time (min)	Infusion concn (mg/ml)	Infusion rate (mg/min)
1	25	100	4 + 2	60	0.25	0.42
2	50	100	4 + 2	60	0.5	0.83
3	125	100	6 + 2	60	1.25	2.08
4	250	100	6 + 2	60	2.5	4.17
5	250	50	6 + 2	45	5	5.56
6	500	100	6 + 2	60	5	8.33
7	750	150	6 + 2	180	5	4.17
8	750	150	6 + 2	135	5	5.56
9	750	150	6 + 2	90	5	8.33
10	1,000	200	6 + 2	240	5	4.17
11	1,000	200	6 + 2	180	5	5.56
12	1,250	250	6 + 2	300	5	4.17

^aTotal subjects was 92.