TABLE 5.
Antifungal activity of FIN in combination with FLC against three urinary isolates (C. albicans UI6, UI5, and UI6)
| Biofilm target (strain) | Agenta | sMIC90 (mg/liter) of each agentb: |
FICI (combination) | Outcomec | |
|---|---|---|---|---|---|
| Alone | In combination | ||||
| Prevention (UI6) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
| Prevention (UI5) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
| Prevention (UI3) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
| Treatment (UI6) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
| Treatment (UI5) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
| Treatment (UI3) | FLC | >256 | >256 | 2.00 | Indifference |
| FIN | >128 | >128 | |||
a
FLC, fluconazole; FIN, finasteride.
b
The sessile minimum inhibitory concentrations indicated correspond to the inhibition of 90% metabolic activity (sMIC90). The inhibition of 90% metabolic activity was not detected in the highest concentration of each agent tested alone; therefore, sMIC90s of antifungals alone are indicated with the sign “>” before their respective concentrations.
c
The outcome represents the interpretation of the FICI values considering the following criteria: synergism, FICI of <0.5; indifference, FICI of >0.5 to <4; and antagonism, FICI of >4.