FIG 2.

Associations between IC₅₀s and pfmdr1 amplification in P. falciparum clinical isolates. Ex vivo drug susceptibility (GM IC₅₀s) for blinded endoperoxides and standard partner drugs against isolates (solid bars) with single (1 copy) and multiple (>1.5 copies) pfmdr1 copies were compared using the Mann-Whitney U test, with significant P values presented. Dashed lines indicate GM IC₅₀s against the P. falciparum W2 clone. The solid line across the MQ, QN, and CQ results represents WHO drug resistance threshold values associated with clinical resistance to these drugs.