TABLE 4.

Cox regression analysis of risk factors for clonal MDR-non-XDR P. aeruginosa intestinal colonization in ICU patients: impact of exposure to antibiotic therapy

Characteristic	Results for crude analysis		Results for adjusted analysis
	cHRa (95% CI)	P	aHR (95% CI)	P
Age > 65 yr	0.77 (0.33–1.80)	0.55	1.20 (0.47–3.04)	0.69
Male gender	1.90 (0.74–4.87)	0.18	0.43 (0.12–1.53)	0.19
SAPS score at ICU admission (>40)	1.23 (0.53–2.87)	0.62
Charlson index of ≥3	2.48 (1.01–6.11)	0.047	2.05 (0.76–5.52)	0.15
Prior hospital stay	0.75 (0.33–1.68)	0.48
Prior non-MDR colonization	0.43 (0.17–1.09)	0.076	0.61 (0.21–1.75)	0.36
Prior fluoroquinolonesb	1.05 (0.960–1.16)	0.23
Prior aminoglycosidesb	114 (0.79–1.64)	0.46
Prior carbapenemsb	0.94 (0.84–1.04)	0.23
Prior ertapenemb	1.07 (1.00–1.15)	0.048	1.10 (1.01–1.19)	0.026
Prior colistinb	0.96 (0.88–1.03)	0.24
Prior antipseudomonal cephalosporinsb	0.96 (0.88–1.05)	0.38
Prior other cephalosporinsb	0.99 (0.97–1.02)	0.95
Prior piperacillin-tazobactamb	0.92 (0.86–0.98)	0.024	0.95 (0.88–1.02)	0.19
Prior penicillinsb	1.27 (0.57–2.84)	0.56
Prior glycopeptidesb	0.96 (0.89–1.03)	0.23

^acHR, crude hazard ratio.

^bAntibiotics per day.