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Emergence of resistance during drug administration versus clinical isolate PAE 2638. Panel A shows the negative-control (no treatment) and active-control (piperacillin-tazobactam at 4.5 g Q6h) study arms, while panel B shows ceftolozane-tazobactam (TOL/TAZ) regimens ranging from 62.5/31.25 to 2,000/1,000 mg delivered Q8h.
