FIG 3.
Anti-HIV-1BaL activity of R4.0 in combination with HIV-1 inhibitors of different classes. (A to F) HIV-1 inhibition tested by acute-infection assays on the human CD4+ T cell clone PM1 and measured by a p24-based assay after 4 days of infection. R4.0 was tested in single combinations with CV-N (A), MVC (B), IDV (C), FTC (D), and TDF (E) and in a triple combination with TDF and IDV (F). The dose-response curves of mixed inhibitors (mix) are referred to as R4.0 (P values < 0.0001). Values are the means ± SD from two independent experiments performed in triplicate.