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The R4.0 and TDF combination inhibits primary R5 HIV-1 strains in acute-infection assays. (A) Inhibition of clade C strain HIV-198IN007; (B) inhibition of clade B strain HIV-15513. The dose-response curves of mixed inhibitors (mix) are referred to as R4.0 (P values < 0.0001). Values are the means ± SD from two independent experiments performed in triplicate.
