TABLE 1.

Antibiotics used as treatments^a

Antibiotic	Humanb		Mouse
	Dose (g, i.v.)	Cmax (μg/ml)	Needed dose (mg/kg)	Cmax (μg/ml)	Dose given (mg/mouse/day)
Cefuroxime	1.5	65	120	50–60	4
Cefotaxime	1	40	60	100	2
Ampicillin	1	40	50	75	1.5
Dicloxacillin	1	30–40	60	90	2
Benzylpenicillin	2 mill. IEb	60	70	60	2
Amdinocillin	0.4	30–40	60	30	2
Meropenem	0.5	26	50	50	1.5
Clindamycin	1.8	6	36	8	1.4
Ciprofloxacin	0.4	4	15	2	0.5

^aAll doses were administered subcutaneously once a day, and the needed doses were calculated based on the expected average weight of the mice (weights given by provider), as described in previously published studies (18–25). All mouse dosages were calculated based on human doses from PK studies performed at SSI or from previously published mouse studies (19–26). i.v., intravenous.

^bBenzylpenicillin (1.2 grams = 2 millions units = 2 mill. IE) was administered intravenously.