TABLE 3.
Summary statistics for metoprolol and alpha-hydroxymetoprolol pharmacokinetic parameter estimates for subjects completing both periods 1 and 2
| Parametera | Metoprolol |
Alpha-hydroxymetoprolol |
||
|---|---|---|---|---|
| Without PA (n = 22) | With PA (n = 22) | Without PA (n = 22)b | With PA (n = 22)b | |
| Half-life (h) | 3.43 (27) | 3.28 (30) | 7.27 (24) | 7.63 (30) |
| Tmax (h) | 1.50 (0.75, 3.00) | 1.00 (0.75, 2.02) | 1.50 (0.75, 8.00) | 1.50 (0.42, 6.00) |
| Cmax (ng/ml) | 154.6 (84) | 228.6 (62) | 69.0 (78) | 66.8 (78) |
| AUC0-t (ng · h/ml) | 712 (101) | 895 (77) | 687 (55) | 601 (72) |
| AUC0–∞ (ng · h/ml) | 777 (98) | 958 (77) | 790 (46) | 742 (51) |
| CL/F (liters/kg/h) | 1.75 (92) | 1.42 (72) | 1.80 (52) | 1.97 (60) |
| Vz/F (liters/kg) | 8.64 (71) | 6.69 (49) | 19.7 (83) | 21.6 (80) |
a
For a given parameter, the summary statistics reflect data only from subjects for whom the parameter was estimable in both periods. The values are expressed as the geometric mean (geometric %CV) for all parameters except Tmax, which is expressed as the median (range).
b
n = 19 for alpha-hydroxymetoprolol half-life and AUC0–∞.