TABLE 6.

Ninety percent confidence intervals for the ratios of computed pharmacokinetic parameters following redosing compared to initial dosing

Parameter by arm	n	Second PA dosing/first PA dosing ratio	Lower limit	Upper limit
Arm A pyronaridine
Cmax	14	90.70	80.17	102.62
AUC0-t	14	100.34	91.48	110.05
AUC0-τ	14	92.53	81.96	104.46
Ctrough	18	125.98	106.24	149.39
AUC0–∞	13	97.74	90.24	105.87
Arm B pyronaridine
Cmax	13	107.37	97.31	118.46
AUC0-t	13	109.56	98.75	121.55
AUC0-τ	13	100.67	91.85	110.33
Ctrough	19	103.01	93.03	114.06
AUC0–∞	12	109.76	98.62	122.16