Representative photomicrographs of longitudinal sections from proximal tibiae, with hematoxylin and eosin staining. Column A, overview of signs of osteomyelitis in the proximal metaphysis. Magnification, ×0. Column B, moderate-to-severe inflammation with massive enlargement and destruction of bone tissue (black arrows) and fibrosis (white arrows) in the PMMA, PMMA-G, and PMMA-C groups and mild inflammation in the PMMA-H group. Magnification, ×40. Column C, moderate-to-severe inflammation with intramedullary abscesses and acute or chronic inflammatory cells (white arrowheads) around necrotic bony trabeculae (black arrowheads) in the PMMA, PMMA-G, and PMMA-C groups and mild inflammation in the PMMA-H group. Magnification, ×200.