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. 2014 Oct;58(10):6068–6078. doi: 10.1128/AAC.02538-14

FIG 1.

FIG 1

Simple allometric scaling relationship with 95% confidence interval (---) for CL of artemether and quinine. Artemether scaling (top) comprised data from 5 studies (▲). The scaled estimate of CL for a 10-kg child (△) was 1.5 liters/h/kg. By comparison, the mean adult CL is 0.88 liter/h/kg (Table 3), the estimated CL based on a fixed exponent of 3/4 is 1.4 liters/h/kg, and the CL from one clinical study in children (9.5 kg) was 1.5 liters/h/kg (150). Quinine scaling (bottom) comprised data from 12 studies (●). The scaled estimate of CL for a 15-kg child (○) was 0.37 liter/h/kg. By comparison, the mean adult CL is 0.17 liter/h/kg (Table 3), the estimated CL based on a fixed exponent of 3/4 is 0.25 liter/h/kg, and the CL from one clinical study in children (15 kg) was 0.24 liter/h/kg (118).