FIG 2.

Allometric scaling relationship for clearance of dihydroartemisinin. (Top) Simple allometric scaling of data from 7 studies (▲). The scaled estimate of CL for a 15-kg child (△) was 2.2 liters/h/kg. By comparison, the mean adult CL is 1.1 liters/h/kg (Table 3), the estimated CL based on a fixed exponent of 3/4 is 1.6 liters/h/kg, and the CL from one clinical study in children (13 kg) was 2.2 liters/h/kg (149). (Bottom) CL × MLP correction (y axis) for the same 7 studies (●). The scaled estimate of CL for a 15-kg child (○) is 0.53 liter/h/kg.