TABLE 1.
Simple allometric scaling data for clearance (CL) of antimalarial drugs in healthy mammals
| Drug | Route of administrationa | No. of speciesb | r2 | Allometric exponent (95% CI) | Allometric coefficient | References |
|---|---|---|---|---|---|---|
| Artesunate | IV | 4 (r, d, p, h) | 0.92 | 0.71 (0.53–0.88) | 7.0 | 55, 58–62 |
| Dihydroartemisinin (from IV artesunate) | IV | 4 (r, d, p, h) | 0.94 | 0.85 (0.68–1.03) | 3.3 | 55, 58–63 |
| Artemether | IM | 3 (r, d, h) | 0.98 | 0.66 (0.38–0.93) | 3.3 | 59, 64–66 |
| Artemether | IM or IV | 4 (r, rb, d, h) | 0.99 | 0.66 (0.56–0.75) | 3.3 | 59, 64–67 |
| Artemisinin | IV, IP, oral×Fc | 3 (m, r, h) | 0.92 | 0.83 (0.69–0.96) | 4.2 | 68–79 |
| Clindamycin | IV | 3 (d, r, h) | 0.98 | 0.62 (0.55–0.69) | 1.4 | 80–87 |
| Piperaquine | Oral | 3 (m, r, h) | 0.99 | 0.96 (0.86–1.05) | 1.6 | 88–92 |
| Mefloquine | Oral | 3 (m, r, h) | 0.90 | 0.52 (0.43–0.61) | 0.2 | 93–110 |
| Quinine | IV | 3 (r, d, h) | 0.89 | 0.40 (0.33–0.47) | 1.9 | 111–123 |
a
IV, intravenous; IM, intramuscular; IP, intraperitoneal.
b
Species: m, mouse; r, rat; d, dog; p, pig; rb, rabbit; h, human.
c
Artemisinin dose was corrected for relative oral bioavailability (oral:intramuscular); F = 0.32 (78).